The 2016-17 Video Game Voice Actor Stike had a major impact on the presentation of the game, forcing a recast of almost all the major characters from Lego Avengers and the previous Lego Marvel Super Heroes game as those actors were all affiliated with the Screen Actors Guild. In addition to the larger world and larger story, Lego Marvel Super Heroes 2 features a larger character roster than before as well, which is crazy since the original title featured 180 heroes. In the game, Kang the Conquerer is building his ultimate city, Chronopolis, by pulling worlds from their own time, allowing a hugely diverse set of locations from Wakanda to Ancient Egypt and beyond to appear as playspaces within the game.
Influences from the Cinematic Universe come from the team wanting to draw in the young crowd who are mostly unfamiliar with the epic comic lore and want to see the funny Racoon and his friends they saw in that one movie do some cool stuff. The story itself isn’t strictly driven by the Movie universe, in an IGN developer interview it was explained that the story was co-written by the team at Travellers Tales and writers at Marvel Comics.
As the Marvel Cinematic Universe has progressed, the team at Traveller’s Tales has gained new material to work with, such as a modern appearance for the Guardians of the Galaxy, who featured in the last game based on Comic Book influences.
Lego Marvel Super Heroes 2 was developed as a direct sequel to Lego Marvel Super Heroes, connecting the new game right over the post credits sequence of the last title.